Maprotiline hydrochloride ( Deprilept; Ludiomil )

Catalog No. M10171 CAS No. 10347-81-6

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Product Name

Maprotiline hydrochloride
Note

Research use only, not for human use.
Brief Description

Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs).
Description

Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does not appear to block serotonin reuptake. Maprotiline may be used to treat depressive affective disorders, including dysthymic disorder (depressive neurosis) and major depressive disorder. Maprotiline is effective at reducing symptoms of anxiety associated with depression.
Synonyms

Deprilept; Ludiomil
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

5-HT; mAChR; Adrenergic Receptor; H1 receptor; Noradrenaline transporter (Sodium-dependent)
Research Area

Neurological Disease
Indication

——

CAS Number

10347-81-6
Formula Weight

313.86
Molecular Formula

C20H24ClN
Purity

>98%(HPLC)
Solubility

Ethanol: 24 mg/mL (76.46 mM); DMSO: 63 mg/mL (200.72 mM)
SMILES

CNCCCC1(CC2)C3=CC=CC=C3C2C4=C1C=CC=C4.Cl
Chemical Name

9-(γ-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene hydrochloride

1.Buckley NA, McManus PR. Drug Saf. 1998 May;18(5):369-8

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